Marie Curie Research Training Network
TRACKS
Transglutaminases: role in pathogenesis, diagnosis and therapy (TRACKS)
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Objective 2 : Role of TGase in Wound Healing and Scarring
The objective of this work package is to further increase our understanding of the involvement of TGs in the biochemical and cellular processes that lead to excessive collagen deposition and scarring so that its modulation using specific inhibitors or targeted antibodies (see objective 4 and 5) provides a means of therapeutic intervention.
Both well established in vitro and experimental models of scarring e.g. renal scarring/dermal wounding and/or liver fibrosis(using chemical inducers) will be used in these studies.
Studies using cell models will investigate the factors important in TG2 expression and secretion following tissue trauma, the effects of TG2 crosslinking on ECM deposition and turnover, collagen contraction , angiogenesis and cell adhesion and migration Studies using experimental models will use TG2 (-/-) knockouts and compare these with wild type controls. The effects of novel TG inhibitors on experimental models of tissue fibrosis and scarring will also be tested
